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KMID : 0371320030640020093
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Journal of the Korean Surgical Society
2003 Volume.64 No. 2 p.93 ~ p.100
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The Immunohistochemical Expression of DNA Topoisomerase Ⅱ-α and E2F-1 in the Breast Carcinoma and Their Relationship with Clinicopathologic Factors
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Kim Hang-Yun
Kim Beom-Gyu
Cha Sung-Jae
Lim Hyun-Muk
Park Sung-Jun
Lee Tae-Jin
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Abstract
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Purpose: Clinical courses of breast cancer are very different, and concern for finding a predictable marker of breast carcinomas has increased. This study focused on the relationship between the expressions of DNA topoisomerase Ⅱ-α as a proliferative marker, and E2F-1 as a transcription factor, with clinicopathological factors of infiltrating duct carcinomas of the breast.
Methods: We investigated the expressions of E2F-1 and DNA topoisomerase Ⅱ-α in 43 patients with infiltrating ductal carcinomas using immunohistochemical staining, and the results were analyzed with regard to clinicopathological
parameters.
Results: Among 43 infiltrating ductal carcinomas, 24 (55.8%) were immunohistochemically negative on E2F-1 and 19 (44.2%) were positive. The expression of E2F-1 correlated with increased tumor size, positive axillary lymph node metastasis and high stage. The topoisomerase Ⅱ-α index correlated with increased tumor size, positive lymph node metastasis, high stage, high histological grade and negative estrogen receptor. The expression of E2F-1 and the topo Ⅱ-α index were significantly correlated.
Conclusion: These results suggest that the expressions of DNA topoisomerase Ⅱ-α and E2F-1 play some role as prognostic factors for infiltrating duct carcinomas of the breast, but much more study will be required.
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KEYWORD
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Infiltrating ductal carcinoma, Breast, Topoisomerase Ⅱ-α, E2F-1
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